Support you need to live with chronic granulomatous disease (CGD)

People with CGD who are prescribed ACTIMMUNE® (Interferon gamma-1b)—as well as their caregivers—have access to TranscendRare, a no-cost HorizonCares program that provides a comprehensive network of services.

The TranscendRare support team includes a dedicated CGD nurse educator and case manager. The nurse educator acts as the main point of contact for all medical questions and concerns about CGD and treatment with ACTIMMUNE®. The case manager works with insurance companies to determine coverage and specialty pharmacies to coordinate delivery of ACTIMMUNE®. Additional support team members help people with CGD and their caregivers connect with others through social media communities, peer mentor programs, and live events.

TranscendRare is committed to improving the lives of people touched by CGD.

Learn more about TranscendRare support services

For more information about TranscendRare, call 1 (877) 305-7704 Monday through Friday from 8 AM to 6 PM ET.

Find additional support and resources from the following organizations dedicated to helping patients and families living with CGD:

Chronic Granulomatous Disease Association

http://www.cgdassociation.org

The Chronic Granulomatous Disease Association is a nonprofit organization dedicated to helping those with CGD and advancing research toward a cure. The group provides helpful disease information, support for parents and patients, and other valuable tools and resources for the CGD community.

Global Genes

https://globalgenes.org

Global Genes is a leading nonprofit organization for patients and families fighting rare and genetic diseases like CGD. Their mission is to provide connections and resources so people can become activists for their disease and feel empowered to keep moving forward.

Immune Deficiency Foundation

http://primaryimmune.org

The Immune Deficiency Foundation (IDF) is a national nonprofit patient organization dedicated to improving the lives of people with different kinds of primary immunodeficiency diseases, such as CGD. IDF provides a wide variety of resources for people with CGD, including information about diagnosis and treatment options, at www.livingwithcgd.org.

Jeffrey Modell Foundation

http://www.info4pi.org

The Jeffrey Modell Foundation is a nonprofit organization devoted to diagnosis, meaningful treatments, and cures for primary immunodeficiency diseases. Thirty years after its creation, the organization continues its mission of hope, advocacy, and action by supporting the medical and global patient community.

National Organization for Rare Disorders

https://rarediseases.org

The National Organization for Rare Disorders (NORD) is a patient advocacy organization dedicated to people with rare diseases and the groups that help them. NORD provides patients and families with helpful advocacy information, assistance programs, and connections to patient organizations.

Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don’t use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are “flu-like” symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.