Watch these videos for more information about living with CGD and see what goes into managing your—or your loved one's—condition.
Dr. Hana Neibur: CGD is a genetic disease, which means it’s passed down from parents to children. There are few different ways that can happen. Sometimes, it’s mothers passing down the gene to sons and daughters. Now, because this can be an X-linked disease, and girls have two X chromosomes, girls end up being carriers. The normal chromosome or the normal expression of the gene allows them to have enough function that they don’t usually have the same problems as a child who’s affected.
But boys get their X chromosome from their mother and their Y chromosome from their father, and so they don’t have that second X chromosome that gives them a normal gene. They only have the gene that causes the problem. So this is why boys are generally affected and girls are generally carriers. There are also autosomal recessive forms of CGD, but it’s carried on a different chromosome, and since you get one copy from each parent, each parent has a bad copy. The parent is not affected. But when a child happens to have the bad luck of getting two bad copies, the child actually has the disease, as opposed to, if they get one bad copy and they’re a carrier, or no bad copies and they’re not affected at all.
Stay updated with helpful information about managing CGD.
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.
Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.
At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.
ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.
Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.
Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.
In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.
Be sure to tell your doctor about all the medications you are taking.
Tell your doctor if you:
The most common side effects with ACTIMMUNE are "flu-like" symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.
Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.
Avoid taking ACTIMMUNE at the same time as a vaccination.
The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.