See more in these videos about chronic granulomatous disease (CGD)

Watch these videos for more information about living with CGD and see what goes into managing your—or your loved one's—condition.

Discovery of CGD

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I went to the University of Minnesota to do an infectious disease fellowship with Dr. Paul Quie. Dr. Quie was a noted infectious disease specialist, who had devised a system where he drew blood from normal individuals. He separated the white cells. Then he put Staph\, or he put E coli, into these test tubes. Your and my cells, which are normal, would basically kill 99.9% of a hundred-thousand bacterial inoculum.

This surgeon had brought down a sample, a blood sample, on a little patient who kept having lymphadenitis infection in the lymph nodes. And Dr. Quie put it into his system and, lo and behold, after 90 minutes, the bacteria were literally growing in the white blood cells.

Slate: What Dr. Quie discovered was a rare genetic disease known now as Chronic Granulomatous Disease (CGD)

From there, we went on to understand that there was a lack of a critical component.

It’s a super-component that helps us kill bacteria. This enzyme in cells, called superoxide dismutase, affects that and it makes hydrogen peroxide. And it’s a very potent and very good anti-bacterial agent.

There’s another component that’s made with another enzyme and the granules of the white blood cells, and it’s called myeloperoxidase, and it takes chloride, which we have in all our cells throughout our body. And it takes it and it makes hypochlorite. That’s Clorox. Clorox is a great way to wipe off things and to kill bacteria. So those are two of the main components, and they end up killing bacteria and fungi in your white blood cells, and you absolutely have to have them.

And these poor, little kids couldn’t make them.

Important Safety Information

What is ACTIMMUNE® (Interferon gamma-1b) used for?

ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.

ACTIMMUNE is also used to slow the worsening of severe, malignant osteopetrosis (SMO). SMO is a genetic disorder that affects normal bone formation and is usually diagnosed in the first few months after birth.

When should I not take ACTIMMUNE?

Don’t use ACTIMMUNE if you are allergic to interferon-gamma, E coli-derived products, or any ingredients contained in the product.

What warnings should I know about ACTIMMUNE?

At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions.

ACTIMMUNE may cause decreased mental status, walking disturbances, and dizziness, particularly at very high doses. These symptoms are usually reversible within a few days upon dose reduction or discontinuation of therapy.

Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.

Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old. Your doctor should monitor your liver function every 3 months, and monthly in children under 1 year.

In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.

What should I tell my healthcare provider?

Be sure to tell your doctor about all the medications you are taking.

Tell your doctor if you:

What are the side effects of ACTIMMUNE?

The most common side effects with ACTIMMUNE are “flu-like” symptoms such as fever, headache, chills, muscle pain, or fatigue, which may decrease in severity as treatment continues. Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.

What other medications might interact with ACTIMMUNE?

Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking.

Avoid taking ACTIMMUNE at the same time as a vaccination.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about ACTIMMUNE with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.ACTIMMUNE.com or 1-866-479-6742.